Messing referenced the recent departure from E! of host Catt Sadler, who has said she was making about half the pay of her male counterpart, Jason Kennedy.
"He is like a brother to me. And in no way do I want this to reflect poorly on him," she said. "He's devastated, I think, and I think he believes that this is a great loss for the network. He does not want to see me go. It's important that people don't vilify him because he isn't the problem. The system's the problem, the structure's the problem."