He hit Lynch on a 9-yard TD in the first quarter, Anthony McCoy for a 6-yarder late in the first half, and Doug Baldwin on 4 and 6 yard TDs in the second half.
Wilson has 25 TD passes, one behind Peyton Manning’s NFL rookie record of 26. He finished 15 of 21 for 171 yards. His only incompletion in the first half was a deflected pass that Patrick Willis intercepted.
Wilson led Seattle on scoring drives of 9, 12, 13 and 15 plays. He was never threatened by Aldon Smith, who remained stuck on 19 1-2 sacks for the season because of the play of Seattle left tackle RussellOkung.
San Francisco’s Colin Kaepernick had already proven himself capable of winning on the road with victories in New Orleans and last week in New England. But Seattle is a different beast, widely regarded by players as the loudest venue in the NFL. His inexperience playing in such an environment showed. He was flustered and disorganized at the line of scrimmage, letting the noise from Seattle’s fans affect him.
Kaepernick’s forgettable night was capped when Sherman stepped in front of his pass for Randy Moss at the back of the end zone on the first play of the fourth quarter for his seventh interception of the season.
Kaepernick was 19 of 36 for 244 yards with an 18-yard TD pass to Delanie Walker with 1:40 left. Frank Gore had just 28 yards on six carries after rushing for a season-high 131 when the teams met in Week 7.
San Francisco played without defensive tackle Justin Smith due to an elbow injury that ended a streak of 185 starts. The 49ers lost tight end Vernon Davis in the first quarter with a concussion sustained when he was knocked off his feet on a huge hit along the sideline from Seattle safety Kam Chancellor that looked legal but drew a penalty for hitting a defenseless receiver.
The injuries kept coming when starting cornerback Tarell Brown was on the ground clutching his right knee early in the second quarter and had to be helped off the field. Brown returned in the second half.
San Francisco wide receiver Mario Manningham went down with a left leg injury early in the third quarter when he was tackled low by Leroy Hill and fumbled.
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