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Panthers 44, Saints 38

NEW ORLEANS — Drew Brees made more NFL history for New Orleans (7-9), but Carolina rallied to win. DeAngelo Williams rushed for 210 yards, including touchdown runs of 54 and 12 yards, for the Panthers (7-9). Brees passed for 396 yards for the Saints, giving him 5,177. That makes him the first player to eclipse 5,000 yards three times. His four TD passes gave him 43 in 2012, and he’s the first player with 40 TD passes in consecutive seasons.

Steelers 24, Browns 10

PITTSBURGH — Ben Roethlisberger threw three short touchdown passes, and Pittsburgh avoided its first losing season in nearly a decade by beating Cleveland. Antonio Brown, Leonard Pope and Plaxico Burress scored for the Steelers (8-8), who for just the second time in the last six weeks.

Giants 42, Eagles 7

EAST RUTHERFORD, N.J. — Eli Manning threw a career-high five touchdown passes, and New York routed Philadelphia in what likely was Andy Reid’s final game as the Eagles’ coach. Manning’s five-TD game came despite completing just 13 of 21 passes for 208 yards, and Ahmad Bradshaw rushed 16 times for 107 yards and a score for the Giants (9-7).

Bills 28, Jets 9

ORCHARD PARK, N.Y. — C.J. Spiller scored on a 66-yard catch and run in helping underachieving Buffalo end its season with a win over New York. Safety Bryan Scott also returned an interception 20 yards for a touchdown for the Bills (6-10), who snapped a three-game skid.

Chargers 24, Raiders 21

SAN DIEGO — Micheal Spurlock returned the opening kickoff 99 yards for a touchdown, and San Diego beat the Oakland Raiders 24-21 on a wet, gloomy day in what’s expected to be Norv Turner’s final game as Chargers coach. Spurlock became the first Chargers player to have a kickoff and punt return for touchdowns in consecutive weeks.

Titans 38, Jaguars 20

NASHVILLE, Tenn. — Tennessee became the first team in NFL history with two players scoring twice on returns in a game in a rout of Jacksonville in the season finale. Darius Reynaud scored on two punt returns and rookie linebacker Zach Brown returned two interceptions for touchdowns.