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Just hours after Mr. Osbon’s breakdown, the crew aboard a US Airways flight from Charlotte, N.C., to Fort Myers, Fla., had to restrain a disruptive female passenger. Lee County Port Authority police spokeswoman Victoria Moreland said a passenger from the flight was arrested Tuesday afternoon but declined to give details.

Earlier this month, an American Airlines flight attendant took over the public-address system on a flight bound for Chicago and spoke for 15 minutes about Sept. 11 and the safety of their plane, saying, “I’m not responsible for this plane crashing,” according to several passengers.

Passengers wrestled the flight attendant into a seat while the plane was grounded at Dallas-Fort Worth International Airport; the flight attendant was hospitalized.

In 2008, an Air Canada co-pilot was removed forcibly from a Toronto-to-London flight, restrained and sedated after having a mental breakdown on a flight.

The FAA is likely to review the captain’s medical certificate — essentially a seal of approval that the pilot is healthy. All pilots working for scheduled airlines must have a first-class medical certificate. The certificates must be renewed every six months to a year, depending on the pilot’s age. To receive the certificate, the pilot must receive a physical examination by an FAA-designated medical examiner that includes questions about pilot’s psychological condition. Pilots are required to disclose all physical and psychological conditions and medications.

Mr. Restivo said he thought it was clear that the pilot had suffered a medical episode.

“I don’t think when he got up this morning that that’s what he was intending to do,” he said. “Unfortunately, I just think it happened to him.”

Betsy Blaney reported from Lubbock. Associated Press writers Samantha Bomkamp in New York and Joan Lowy in Washington contributed to this report.