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The crash is the latest in a series of bus accidents in the Northeast this year, though most of those involved smaller operators and chartered tour buses, not commercial carriers.

More than 30 people have been killed and more than 300 injured in tour bus accidents this year, according to Advocates for Highway and Auto Safety. That’s more than in all of last year, when there 30 killed and 272 injured in 28 crashes.

Tour bus industry safety has drawn heightened attention since the March crash of a bus returning to New York City’s Chinatown after an overnight excursion to a Connecticut casino. Fifteen people were killed when the bus flipped onto its side and struck a pole, peeling off its roof.

Greyhound set up a hotline — (800) 972-4583 — for relatives and friends to get information about people on the bus that crashed in Pennsylvania.

The federal Motor Carrier Safety Administration said it was working with state police in their investigation. A spokeswoman referred further questions to state police.

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Associated Press writer Ron Todt in Philadelphia contributed to this report.