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What will the Colts do with 10 picks next weekend?

Take the best player available, of course.

“You never want to pass on a really good football player,” Grigson said. “You usually know the guys you like pretty quickly. You want guys who know how to play the game first and foremost.”

Where else could the Colts look? Offensive line.

While rookie left tackle Anthony Castonzo was solid in 2011, second-round pick Ben Ijalana was lost to a season-ending knee injury in early October, longtime center Jeff Saturday left for Green Bay in free agency and the Colts have spent the past several years looking for help at guard.

“There are some good quality offensive linemen in this draft,” Grigson said when asked what position had the greatest depth this year. “The underclassmen that declared helped that crop quite a bit. I’d say offensive line is pretty solid.”

Grigson knows the position well. He played on the offensive line at Purdue and for two years in the NFL.

Of course, the success or failure of Grigson’s first draft as a general manager will be dictated by the one pick that’s no secret.

“I don’t think I’ve ever picked anywhere near the top,” Grigson said referring to previous scouting jobs at St. Louis and Philadelphia. “I think I’ve only been part of two teams with losing records since I’ve been doing this about 12 years or so. I’ve always been toward the bottom so it’s been a little bit different.”